Email：hezhi2003@126.com 电话：0717-6397378
何治，1978年7月生，湖北浠水人，医学博士，教授，博士/硕士研究生导师，湖北省高等学校优秀中青年科技创新团队负责人，bat365在线官网登录“151”学术带头人，湖北省新世纪高层次人才工程人选，湖北省青年博士“晨光计划”人选，国家自然科学基金同行评议专家，教育部学位中心学位论文评审专家，湖北省药理学会常务理事。
现任bat365在线官网登录医学院经理，曾任bat365在线官网登录研究生院副经理、学科规划与建设办公室副主任。2008年获华中科技大学药理学专业博士学位，2012-2013年德国美因茨大学医学中心访问学者。目前主要从事脑卒中、药物成瘾等神经系统疾病发病机理及相关防治药物的研究，围绕HCN通道（超极化激活环核苷酸门控阳离子通道）与脑缺血及药物成瘾、ALPHA肾上腺素受体与脑缺血、天然药物的抗脑缺血作用及机制等研究领域开展工作。
承担的主要科研项目：
1. 国家自然科学基金 (主持)：HCN通道功能抑制对脑缺血的保护作用及相关分子机制研究；
2. 国家自然科学基金 (主持)：从"聪明基因"NR2B途径探讨α2肾上腺素受体激动剂对血管性痴呆大鼠认知功能的调节作用
3. 湖北省高等学校优秀中青年科技创新团队（负责人）：神经药理学
代表性研究论文
1.Yanli Li, Min Yu, Bo Zhao, Yan Wang, Yunhong Zha, Zicheng Li, Lingling Yu,
lingling Yan, Zhangao Chen, Wenjuan Zhang, Xiaoli Zeng, Zhi He (通讯作者). Clonidine preconditioning improved cerebral ischemia-induced learning and memory deficits in rats via ERK1/2-CREB/ NF-κB-NR2B pathway. European Journal of Pharmacology (2018), 818, 167-173
2.Li Yanli, Zhang Xizhou , Wang Yan, Zhao Bo, Zha Yunhong, Li Zicheng, Yu Lingling,
Yan lingling, Chen Zhangao, Zheng Min, He Zhi (通讯作者). Clonidine preconditioning alleviated focal cerebral ischemic insult in rats via up-regulating p-NMDAR1 and down-regulating NMDAR2A / p-NMDAR2B. European Journal of Pharmacology
(2016), 793, 89-94.
3. Yun Lu, Chang-jun Li , Cheng Chen, Pan Luo, Mei Zhou, Cai Li , Xu-lin Xu , Qing Lu, Zhi He (通讯作者), Lian-jun Guo. Activation of GABAB2 subunits alleviates chronic cerebral
hypoperfusion-induced anxiety-like behaviours: A role for BDNF signalling and Kir3 channels. Neuropharmacology 110 (2016) 308-321
4. Pan Luo, Cheng Chen, Yun Lu, TianLi Fu, Qing Lu, Xulin Xu, Changjun Li, Zhi He (通讯作者), Lianjun Guo. Baclofen ameliorates spatial working memory impairments induced by chronic cerebral hypoperfusion via up-regulation of HCN2 expression in the PFC in rats. Behavioural Brain Research, 2016, 308, 6–13
5. Yun Lu, Changjun Li, Mei Zhou, Pan Luo, Pengcheng Huang, Jiahong Tan, Qing Lu, Xulin Xu, Zhi He (通讯作者), Lianjun Guo. Clonidine ameliorates cognitive impairment induced by chronic cerebral hypoperfusion via up-regulation of the GABABR1 and GAD67 in hippocampal CA1 in rats. Pharmacology, Biochemistry and Behavior, 2015, 132, 96-102
6. Pan Luo, Yun Lu, Changjun Li, Mei Zhou, Cheng Chen, Qing Lu, Xulin Xu, Zhi He(通讯作者), Lianjun Guo. Long-lasting spatial learning and memory impairments caused by chronic cerebral hypoperfusion associate with a dynamic change of HCN1/HCN2 expression in hippocampal CA1 region. Neurobiology of Learning and Memory, 2015, 123, 72-83.
7. Mei Zhou, Pan Luo, Yun Lu, Chang-jun Li, Dian-shiWang, Qing Lu, Xu-lin Xu, Zhi He(通讯作者) , Lian-jun Guo. Imbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure. Progress in Neuro-Psychopharmacology & BiologicalPsychiatry. 2015,56, 207–214
8. You Yan, Yu Min, Hu Min, Chen Chao, Qian Ying, He Zhi (通讯作者). n-butanol soluble fraction of the water extract of Chinese toon fruit ameliorated focal brain ischemic insult in rats via inhibition of oxidative stress and inflammation. Journal of Ethnopharmacology，2014,151:176-782
9. He Zhi, Hu Min, Zha Yun-hong, Li Zi-cheng, Zhao Bo, Yu Ling-ling, Yu Min, Qian Ying. Piracetam ameliorated oxygen and glucose deprivation-induced injury in rat cortical neurons via inhibition of oxidative stress, excitatory amino acids release and P53/Bax. Cell Mol Neurobiol 2014，34:539–547
10. S. Li, Z. He（并列第一作者）, L. Guo， L. Huang, J. Wang, W. He. Behavioral alterations associated with a down regulation of HCN1 mRNA in hippocampal cornus ammon 1 region and neocortex after chronic incomplete global cerebral ischemia in rats. Neuroscience, 2010, 165, 654–661.
11. Lin Huang, Zhi He（并列第一作者）, Lianjun Guo, Hongxing Wang. Improvement of Cognitive Deficit and Neuronal Damage In Rats with Chronic Cerebral Ischemia via Relative Long-term Inhibition of Rho-kinase. Cell Mol Neurobiol, 2008. 28(5):757-68.
12. Zhi He, Lin Huang, Yan Wu，Jianzhi Wang, Hongxing Wang, Lianjun Guo. DDPH: Improving cognitive deficits beyond its α1-adrenergic receptor antagonism in chronic cerebral hypoperfused rats. Eur J of Pharmacol. 2008, 588:178-188
13. Zhi He, Yun Liao, Min Zheng, Fan-Dian Zeng, Lian-Jun Guo. Piracetam Improves Cognitive Deficits Caused by Chronic Cerebral Hypoperfusion in Rats. Cell Mol Neurobiol, 2008, 28:613-627.
14. Zhi He, Qing Lu, Xulin Xu, Lin Huang, Jianguo Chen, Lianjun Guo. DDPH ameliorated oxygen and glucose deprivation-induced injury in rat hippocampal neurons via interrupting Ca2+ overload and glutamate release. Eur J of Pharmacol. 2009，603:50-55
