袁成福,博士,教授,博士/硕士生导师。国家自然科学基金通讯评审专家,教育部学位中心学位论文评审专家;Seminars in Cancer Biology、International Journal of Biological Macromolecules、ACS Applied Materials & Interfaces、Food and function、Food and Nutrition Research、Scientific Reports、Anti-Cancer Agents in Medicinal Chemistry、Current Pharmaceutical Analysis、Journal of Basic and Clinical Physiology and Pharmacology、Carbohydrate Polymers、Natural Product Research、Genes & Diseases等30余种国际期刊审稿专家。
2010年至2014年于美国University of Minnesota等大学进行医学分子生物学博士后研究;2017年8月至2018年8月于美国The University of Chicago访问学习。
主要研究方向:
1. 代谢性疾病(如肥胖、胰岛素抵抗、NAFLD等)发病机制及药物防治;
2. 恶性肿瘤相关新基因的挖掘、筛选、功能解析及其临床应用评价研究。
招生方向:临床医学(学术型);基础医学;药学
联系方式:yuancf46@ctgu.edu.cn; yuancf46@163.com;340319417@qq.com
近几年代表性研究论文(第一或通讯作者*发表的SCI收录论文):
1. Luoying Li#, Yifan Zhang#, Yan Gao, Yaqi Hu, Rui Wang, Shuwen Wang, Yuanyang Li, Yumin He, Chengfu Yuan*. LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells. Cancer Gene Ther, 2023, doi: 10.1038/s41417-022-00581-z.
2. Xia F, Wang Y, Xue M, Zhu L, Jia D, Shi Y, Gao Y, Li L, Li Y, Chen S, Xu G, Yuan D, Yuan C*. LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases. Genes & Diseases, 2021,9(6):1556-1565. doi: 10.1016/j.gendis.2021.07.003. eCollection 2022 Nov. PMID: 36157505
3. Zhao F, Tan F, Tang L, Du Z, Chen X, Yang Y, Zhou G, Yuan C*.Long non-coding RNA DLGAP1-AS1 and DLGAP1-AS2:Two novel oncogenes in multiple cancers. Curr Med Chem. 2022 Sep 19. doi: 10.2174/0929867329666220919114919. PMID: 36121088
4. Mou J, Chen J, Wu Y, He Y, Zhou G, Yuan C*. WDFY3-AS2: a potential prognostic factor and therapeutic target related to cancer. Curr Med Chem. 2022 Sep 9. doi: 10.2174/0929867329666220909114416. PMID: 36093824
5. Wang Z, Wu Y, Du Z, Tan F, Zhou Y, Zhang Z, Yuan C*. The Dual Functions of Non-Coding RNA CRNDE in Different Tumors. Mini Rev Med Chem. 2022 Aug 26. doi: 10.2174/1389557522666220826124836. PMID: 36029079
6. Wu Y, Du Z, Mou J, Qiu X, Chen J, Cai S, Ren D, Xiao F, Zhou G, Yuan C*. The Functions of EphA1 receptor tyrosine kinase in Several Tumors. Curr Med Chem. 2022 Aug 20. doi: 10.2174/0929867329666220820125638. PMID: 35996244
7. Jia D, He Y, Wang Y, Xue M, Zhu L, Xia F, Li Y, Gao Y, Li L, Chen S, Xu G, Yuan C*. NEAT1: A Novel Long Non-coding RNA Involved in Mediating Type 2 Diabetes and its Various Complications. Curr Pharm Des. 2022,28(16):1342-1350. doi: 10.2174/1381612828666220428093207. PMID: 35974675
8. Zhao F, Liu Y, Tan F, Tang L, Du Z, Mou J, Zhou G, Yuan C*. MIR4435-2HG: A Tumor-associated Long Non-coding RNA. Curr Pharm Des. 2022;28(25):2043-2051. doi: 10.2174/1381612828666220607100228.PMID: 35674305
9. Liu Y, Zhao F, Tan F, Tang L, Du Z, Mou J, Zhou G, Yuan C*. HNF1A-AS1: A Tumor-associated Long Non-coding RNA. Curr Pharm Des. 2022;28(21):1720-1729.doi: 10.2174/1381612828666220520113846.PMID: 35619319
10. Du Z, Tan F, Chen J, Wang B, Liu Y, Zhao F, Wu Y, Yuan C*. MEG8: An Indispensable Long Non-coding RNA in Multiple Cancers. Curr Pharm Des. 2022;28(20):1688-1694. doi: 10.2174/1381612828666220516090245.PMID: 3557884
11. Wu Y, Chen J, Tan F, Wang B, Xu W, Yuan C*. ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors. Curr Pharm Des. 2022;28(17):1412-1418. doi: 10.2174/1381612828666220501165644.PMID: 35490433
12. Tan F, Chen J, Wang B, Du Z, Mou J, Wu Y, Liu Y, Zhao F, Yuan C*. LncRNA SBF2-AS1: A Budding Star in Various Cancers. Curr Pharm Des. 2022;28(18):1513-1522. doi: 10.2174/1381612828666220418131506.PMID: 35440300
13. Mou J, Wang B, Liu Y, Zhao F, Wu Y, Xu W, Zeng D, Zhang Q, Yuan C*. FER1L4: A Long Non-coding RNA with Multiple Roles in the Occurrence and Development of Tumors. Curr Pharm Des. 2022;28(16):1334-1341. doi: 10.2174/1381612828666220324141016. PMID: 35331091
14. Tan F, Chen J, Du Z, Zhao F, Liu Y, Zhang Q, Yuan C*. MIR17HG: A Cancerogenic Long-Noncoding RNA in Different Cancers. Curr Pharm Des. 2022;28(15):1272-1281. doi: 10.2174/1381612828666220310144500.PMID: 35272588
15. Wang B, Chen J, Lin C, Liu R, Wang L, Yuan C*. MCM3AP-AS1: A LncRNA Participating in the Tumorigenesis of Cancer Through Multiple Pathways. Mini Rev Med Chem. 2022;22(16):2138-2145. doi: 10.2174/1389557522666220214100718. PMID: 35156580
16. Xu W, Wang B, Cai Y, Chen J, Meng E, Guo C, Zhou G, Yuan C*. The Therapeutic Value and Molecular Mechanisms of lncRNA FENDRR in Human Cancer. Curr Pharm Des. 2021;27(39):4100-4106. doi: 10.2174/1381612827666210820094702.PMID: 34414867
17. Xue M, Xia F, Wang Y, Zhu L, Li Y, Jia D, Gao Y, Shi U, Zhang C, He Y, Liu C, Yuan D, Yuan C*. The Role of LncRNA TUG1 in Obesity-Related Diseases.Mini Rev Med Chem. 2022 Jan 17.doi:10.2174/1389557522666220117120228. PMID: 35040400
18. Li Y, Zhu L, Guo C, Xue M, Xia F, Wang Y, Jia D, Li L, Gao Y, Shi Y, He Y, Yuan C*.Dietary Intake of Hydrolyzable Tannins and Condensed Tannins to Regulate Lipid Metabolism..Mini Rev Med Chem. 2021 Dec 29. doi: 10.2174/1389557522666211229112223. PMID: 34967286
19. Zhu L, Li Y, Xia F, Xue M, Wang Y, Jia D, Gao Y, Li L, Shi Y, Chen S, Xu G, Yuan C*. H19: A vital long noncoding RNA in the treatment of diabetes and diabetic complications.Curr Pharm Des. 2021 Dec 10. doi: 10.2174/1381612827666211210123959. PMID: 34895118
20. Chen X, Liu K, Xu W, Zhou G, Yuan C*. Tumor-Related Molecular Regulatory Mechanisms of Long Non-Coding RNA RMST: Recent Evidence.Mini Rev Med Chem. 2021 Dec 2. doi: 10.2174/1389557521666211202150646. PMID: 34856896
21. Wang Y, Xue M, Xia F, Zhu L, Jia D, Gao Y, Li L, Shi Y, Li Y, Chen S, Xu G, Yuan C*. Long noncoding RNA GAS5 in age-related diseases. Curr Med Chem. 2021 Oct 27. doi: 10.2174/0929867328666211027123932. PMID: 34711157
22. Xu W, Wang B, Gao Y, Cai Y, Zhang J, Wu Z, Wei J, Guo C, Yuan C*. Alkaloids exhibit a meaningful function as anticancer agents by restraining cellular signaling pathways. Mini Rev Med Chem. 2021 Oct 7. doi: 10.2174/1389557521666211007114935. PMID: 34620048
23. Zhong J, Chen J, Wang B, Zhou Z, Shen Y, Gong Y, Tan F, Yuan C*. OIP5-AS1: A fascinating long noncoding RNA in carcinoma. Curr Pharm Des. 2021 Sep 26. doi: 10.2174/1381612827666210927105558. PMID: 34579624
24. Zhang Q, Wu Y, Chen J, Cai Y, Wang B, Tan F, Mou J, Yuan C*. The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common Cancers. Curr Pharm Des. 2021 Aug 29. doi: 10.2174/1381612827666210830110732. PMID: 34459372
25. Hu C, Xu W, Wang B, Chen J, Zhou Z, Zhou G, Yuan C*. Critical functions of lncRNA DGCR5 in cancers of the digestive system. Curr Pharm Des. 2021 Aug 12. doi: 10.2174/1381612827666210812130455. PMID: 34387158
26. Wang B, Xu W, Cai Y, Chen J, Guo C, Zhou G, Yuan C*. DUXAP8: a promising lncRNA with carcinogenic potential in cancer. Curr Med Chem, 2021 Jul. doi: 10.2174/0929867328666210726092020. PMID: 34313198
27. Chen J, Meng E, Lin Y, Shen Y, Hu C, Zhou G, Yuan C*. The Role of Tumor-related LncRNA PART1 in cancer. Curr Pharm Des. 2021 Jul. doi: 10.2174/1381612827666210705161955. PMID: 34225608
28. Cai Y, Wang B, Xu W, Liu K, Gao Y, Guo C, Chen J, Kamal MA, Yuan C*. Endometrial Cancer: genetic, metabolic characteristics, therapeutic strategies and nanomedicine.Curr Med Chem. 2021 Jul. doi:10.2174/0929867328666210705144456. PMID: 34225603
29. Gao X, Zhang K, Zhou H, Zellmer L, Yuan C*, Huang H, Liao DJ. At elevated temperatures, heat shock protein genes show altered ratios of different RNAs and expression of new RNAs, including several novel HSPB1 mRNAs encoding HSP27 protein isoforms. Exp Ther Med. 2021 Aug;22(2):900. doi: 10.3892/etm.2021.10332. PMID: 34257713 (Co-corresponding author)
30. Wang B, Xu W, Cai Y, Liu K, Wu J, Guo C, Yuan C*. The functional role of oncogenic lncRNA BCAR4 for cancer outcome. Curr Pharm Des. 2021 Jun. doi: 10.2174/1381612827666210604114955. PMID: 34086548
31. Xu W, Ding M, Wang B, Cai Y, Guo C, Yuan C*. Molecular mechanism of the canonical oncogenic lncRNA MALAT1 in gastric cancer. Curr Med Chem. 2021 May. doi: 10.2174/0929867328666210521213352. PMID: 340369053
32. Xu W, Wang B, Cai Y, Chen J, Lv X, Guo C, Yuan C*. ADAMTS9-AS2: A functional long non-coding RNA in tumorigenesis. Curr Pharm Des. 2021 Mar. doi: 10.2174/1381612827666210325105106. PMID: 33823762
33. Yue Shi, Zhengtai Liu, Liyue Gai, Yan Gao, Yumin He, Chaoqi Liu, Changcheng Zhang, Gang Zhou, Ding Yuan, Chengfu Yuan*. The preventive effect of total saponins from Panax japonicus on inflammation and insulin resistance in adipose tissue of mice induced by a high-fat diet. Journal of Functional Foods, 2021,78. doi.org/10.1016/j.jff.2021.104369
34. Yan Gao, Ding Yuan, Liyue Gai, Xuelian Wu, Yue Shi, Yumin He, Chaoqi Liu, Changcheng Zhang, Gang Zhou, Chengfu Yuan*. Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-kB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling. Journal of Ginseng Research, 2020,8. doi.org/10.1016/j.jgr.2020.08.005
35. Luoying Li, Gang Zhou, Rui Fu, Yumin He, Li Xiao, Fan Peng, Chengfu Yuan*. Polysaccharides extracted from balanophora polyandra Griff (BPP) ameliorate renal fibrosis and EMT via inhibiting the hedgehog pathway. J Cell Mol Med, 2021, doi: 10.1111/jcmm.16313. PMID:33507617
36. Hao Yuan, Xuelian Wu, Xiaomin Wang, Chengfu Yuan*. Chinese herbal decoction astragalus and angelica exerts its therapeutic effect on renal interstitial fibrosis through the inhibition of MAPK, PI3K-Akt and TNF signaling pathways. Genes & Diseases, 2020,6. doi.org/10.1016/j.gendis.2020.06.001
37. Bei Wang, Wen Xu, Chengyu Hu, Kai Liu, Jinlan Chen,Chong Guo, Chengfu Yuan*. Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential. Genes & Diseases, 2020,11. doi.org/10.1016/j.gendis.2020.11.016
38. Chong Guo, Chaoying Song, Jiali Zhang, Yisong Gao,Yuying Qi, Zongyao Zhao, Chengfu Yuan*. Revisiting chemoresistance in ovarian cancer: Mechanism, biomarkers, and precision medicine. Genes & Diseases, 2020,11. doi.org/10.1016/ j.gendis.2020.11.017
39. Bei Wang, Wen Xu, Yuxuan Cai, Chong Guo, Gang Zhou, Chengfu Yuan*. CASC15: A Tumor-Associated Long Non-Coding RNA. Curr Pharm Des, 2021;27(1):127-134.
40. Yujie Shen, Yexiang Lin, Kai Liu, Jinlan Chen, Juanjuan Zhong, Yisong Gao, Chengfu Yuan*. XIST: A Meaningful Long Noncoding RNA in NSCLC Process. Curr Pharm Des, 2020, doi: 10.2174/1381612826999201202102413.PMID: 33267757
41. Yexiang Lin , Yujie Sheng , Jinlan Chen , Chengyu Hu , Zixian Zhou , Chengfu Yuan*. The Function of LncRNA FTX in Several Common Cancers. Curr Pharm Des, 2020, doi: 10.2174/1381612826666201029164036.PMID:33121404
42. Chengyu Hu, Kai Liu, Bei Wang, Wen Xu, Yexiang Ling, Chengfu Yuan*. DLX6-AS1: An Indispensable Cancer-related Long Non-coding RNA. Curr Pharm Des, 2020, doi: 10.2174/1381612826666201029100151.PMID:33121401
43. Wen Xu, Bei Wang, Yuxuan Cai, Chong Guo, Kai Liu, Chengfu Yuan*. DLEU2: A Meaningful Long Noncoding RNA in Oncogenesis. Curr Pharm Des, 2020, doi: 10.2174/1381612826666201026150857. PMID: 33106136
44. Li Xiao, Yumin He, Fan Peng, Jianlin Yang, Chengfu Yuan*. Endometrial Cancer Cells Promote M2-Like Macrophage Polarization by Delivering Exosomal miRNA-21 under Hypoxia Condition. J Immunol Res, 2020,2020:9731049. doi: 10.1155/2020/9731049. eCollection 2020.PMID:33110923
45. Yuying Qi, Chaoying Song, Jiali Zhang, Chong Guo, Chengfu Yuan*. Oncogenic LncRNA CASC9 in Cancer Progression. Curr Pharm Des, 2020, doi: 10.2174/1381612826666200917150130. PMID:32940174
46. Chong Guo, Yumin He, Liyue Gai, Jiayuan Qu, Yue Shi, Wen Xu, Yuxuan Cai, Bei Wang, Jiali Zhang, Zongyao Zhao, Chengfu Yuan*. Balanophora polyandra Griff. prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome. Food Funct, 2020,11(7):6104-6114.
47. Jiayuan Qu, Yumin He, Yue Shi, Liyue Gai, Li Xiao, Fan Peng, Zicheng Li, Xiaomin Wang, Chengfu Yuan*. Polysaccharides derived from Balanophora polyandra significantly suppressed the proliferation of ovarian cancer cells through P53-mediated pathway. J Cell Mol Med, 2020,24(14):8115-8125.
48. Chaoying Song, Yuying Qi, Jiali Zhang, Chong Guo, Chengfu Yuan*. CDKN2B-AS1: An Indispensable Long Non-coding RNA in Multiple Diseases. Curr Pharm Des, 2020,26(41):5335-5346.
49. Yue Shi, Jiayuan Qu, Liyue Gai, Ding Yuan, Chengfu Yuan*. Long Non-coding RNAs in Metabolic and Inflammatory Pathways in Obesity. Curr Pharm Des, 2020,26(27):3317-3325.
50. Chaoying Song, Jiali Zhang, Zongyao Zhao, Yuxia Yang, Di Meng, Jing Wang, Chong Guo, Chengfu Yuan*. DLEU1: A Functional Long Noncoding RNA in Tumorigenesis. Curr Pharm Des, 2020,26(15):1742-1748.
51. Chong Guo, Yuying Qi, Jiayuan Qu, Liyue Gai, Yue Shi, Chengfu Yuan*. Pathophysiological Functions of the lncRNA TUG1. Curr Pharm Des, 2020,26(6):688-700.
52. Jiayuan Qu, Mohammad Amjad Kamal, Chengfu Yuan*. The Regulatory Roles of Long Non-Coding RNA in the Chemoresistance Process of Ovarian cancer. Curr Pharm Des. 2019;25(8):856-861.
53. Yan He, Chengfu Yuan*, Lichan Chen, Mingjuan Lei, Lucas Zellmer, Hai Huang, and Dezhong Joshua Liao. Transcriptional-Readthrough RNAs Reflect the Phenomenon of “A Gene Contains Gene(s)” or “Gene(s) within a Gene” in the Human Genome, and Thus Are Not Chimeric RNAs. Genes (Basel), 2018, 9(1). pii: E40. doi: 10.3390/genes9010040.
54. Yan He, Chengfu Yuan*, Lichan Chen, Yanjie Liu, Haiyan Zhou, Ningzhi Xu, and Dezhong Joshua Liao.*While it is not deliberate, much of today’s biomedical research contains logical and technical flaws, showing a need for corrective action. Int J Med Sci, 2018, 15(4):309-322. doi: 10.7150/ijms.23215. eCollection 2018.
55. Chengfu Yuan*, Yaping Han, Lucas Zellmer, Wenxiu Yang, Zhizhong Guan, Wenfeng Yu, Hai Huang, D. Joshua Liao. It is imperative to establish a pellucid definition of chimeric RNA and to clear up a lot of confusion in the relevant research. Int J Mol Sci, 2017, 18(4). pii: E714. doi: 10.3390/ijms18040714.
56. Chengfu Yuan,Chaoqi Liu,Ting Wang,Yumin He,Zhiyong Zhou,Yaoyan Dun,Haixia Zhao,Dongming Ren,Junjie Wang*,Changcheng Zhang,Ding Yuan. Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF-κB signaling. Oncotarget, 2017,8(19):31023-31040. DOI: 10.18632/oncotarget.16052.
57. Fan Peng,Xin Guo,Zhihong L#,Changzheng Li,Changdong Wang,Weiran Lv,Junjie Wang,Fangxiang Xiao,Mohammad Amjad Kamal,Chengfu Yuan*. Antimutagenic Effects of Selenium-Enriched Polysaccharides from Pyracantha fortuneana through Suppression of Cytochrome P450 1A Subfamily in the Mouse Liver. Molecules, 2016, 21(12). pii: E1731. doi: 10.3390/molecules21121731.
58. Qianling Sun,Mengmeng Dong,Zhihui Wang,Changdong Wang,Deqiao Sheng,Zhihong Li,Debin Huang,Chengfu Yuan*. Selenium-enriched polysaccharides from Pyracantha fortuneana (Se-PFPs) inhibit the growth and invasive potential of ovarian cancer cells through inhibiting β-catenin signaling. Oncotarget,2016,7(19):28369-28383. doi: 10.18632/oncotarget.8619.
59. Chengfu Yuan*,Changdong Wang,Junjie Wang,Vikas Kumar,Firoz Anwar,Fangxiang Xiao,Gohar Mushtaq,Yufei Liu,Mohammad Amjad Kamal,Ding Yuan. Inhibition on the growth of human MDA-MB-231 breast cancer cells in vitro and tumor growth in a mouse xenograft model by Se-containing polysaccharides from Pyracantha fortuneana. Nutr Res, 2016, 36(11):1243-1254.
60. Chengfu Yuan*,Zhihong Li,Fan Peng,Fangxiang Xiao,Dongming Ren,Hui Xue,Tao Chen,GoharMushtaq,Mohammad Amjad Kamal.Combination of selenium-enriched green tea polysaccharides and Huo-ji polysaccharides synergistically enhances antioxidant and immune activity in mice. J Sci Food Agric, 2015, 95(15): 3211-3217.
61. Chengfu Yuan*,Zhihong Li,Muhua Yi,Xiaoxing Wang,Fan Peng,Fangxiang Xiao,Tao Chen,Changdong Wang,Gohar Mushtaq,Mohammad Amjad Kamal. Effects of polysaccharides from selenium-enriched Pyracantha fortuneana on mice liver injury. Med Chem, 2015, 11(8):780-788.
62. Jinglei Zhang,Chengfu Yuan,Jianguo Wu,Zeinab Elsayed,Zheng Fu,Polo-like Kinase 1-mediated Phosphorylation of Forkhead Box Protein M1b Antagonizes Its SUMOylation and Facilitates Its Mitotic Function.J Biol Chem, 2015, 290(6):3708-3719.
63. Chengfu Yuan,Lei Wang,Liang Zhou,Zheng Fu. The function of FOXO1 in the late phases of the cell cycle is suppressed by PLK1-mediated phosphorylation. Cell Cycle,2014, 13(5):807-819.
64. Chengfu Yuan,Yongming Liu,Min Yang,Joshua Liao. New methods as alternative or corrective measures for the pitfalls and artifacts of reverse transcription and polymerase chain reactions (RT-PCR) in cloning chimeric or antisense-accompanied RNA.RNA Biol,2013,10(6):958-967.
65. Chengfu Yuan,Ningzhi Xu,Joshua Liao*. Switch of FANCL, a key FA-BRCA component, between tumor suppressor and promoter by alternative splicing. Cell Cycle,2012, 11(18):3356-3356.
66. Chengfu Yuan,Youquan Bu,Changdong Wang,Faping Yi,Zhengmei Yang,Xiuning Huang,Li Cheng,Geli Liu,Yong Wang,Fangzhou Song*. NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer. Mol Cell Biochem,2012, 359(1-2): 333-346.
67. Chengfu Yuan,Changdong Wang,Youquan Bu,Tingxiu Xiang,Xiuning Huang,Zhiwei Wang,Faping Yi,Guosheng Ren,Geli Liu,Fangzhou Song. Antioxidative and immunoprotective effects of Pyracantha fortuneana (Maxim.) Li polysaccharides in mice. Immunol Lett,2010, 133(1):14-18.
68. Chengfu Yuan,Weiping Lu,Tingxiu Xiang,Faping Yi,Geli Liu,Guosheng Ren,Fangzhou Song. Generation of mammalian cell lines with gene knock-down for human MCHR2.Cell.Mol.Biol.,2010,56:OL1359-OL1365.
69. Chengfu Yuan,Xiuning Huang,Li Cheng,Youquan Bu,Geli Liu,Faping Yi,Zhengmei Yang,Fangzhou Song*. Evaluation of antioxidant and immune activity of Phellinus ribis glucan in mice. Food Chem,2009,115(2):581-584.
70. Chengfu Yuan,Youquan Bu,Joyeeta Sengupta,Junxia Yang,Xiuning Huang,Li Cheng,Qin Zhang,Faping Yi,Geli Liu,Fangzhou Song*. Establishment of CHO cell line expressing human MCHR2 gene and research of its molecular characteristics. Indian J Exp Biol, 2009,47(11):862-870.